Wednesday | February 8th, 2017

14.30 - 15.00

Welcome and opening the course

Prof. Dr. Lászlo Hunyady (Dean Semmelweis University, Faculty of Medicine)


Session 1: Genetic and genomic alterations in endocrine tumours, focusing on high throughput methods

Chairs: Márta Korbonits (London, UK) and Péter Igaz (Budapest, Hungary)

15.00-15.30Genetics of adrenocortical tumors focusing on methods and interpretation of results
Guillaume Assie
(Paris, France)
15.30-16.00NGS in genetic diagnosis of Pheo/PGL exome and targeted resequencing, results and pitfalls
Joakim Crona
(Department of Surgical Sciences, Uppsala University, SE-75185, Uppsala Sweden) 
16.00-16.15Selected Oral communication
OP1: Analytical performance of exome sequencing in molecular genetic diagnosis of pheochromocytoma/paraganglioma
Balázs Sarkadi
(HAS-SE “Lendulet” Hereditary Endocrine Tumors Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary)


Coffee break 


Interpretation of genetic results and their consequences in endocrine tumour syndromes
Francesca Marini
(University of Florence, Florence, Italy)

17.15-17.30Selected Oral communication
OP2: Analysis of MEN1 mutations and potentially MEN1-targeting miRNAs in sporadic and MEN-1 syndrome associated primary hyperparathyroidism
Vince Kornél
Grolmusz Lendület” Hereditary Endocrine Tumours Research Group, Hungarian Academy of Sciences - Semmelweis University, Budapest, Hungary
17.30-17.45Selected Oral communication
OP3: Molecular analysis of the PAX8-PPARγ and RET/PTC rearrangements in follicular cell-derived thyroid tumors in Polish population
Karolina Czarnecka
(Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland)

19.00 – 

Welcome reception

Thursday | February 9th, 2017


Session 2: Neuroendocrinology

Chairs: Krisztina Kovacs (Budapest, Hungary)

09.00-09.30 Central neuronal pathways in the regulation of energy homeostasis
Csaba Fekete
(Institute of Experimental Medicine, Budapest, Hungary)

Examination of the central control of energy homeostasis using metabolic profiling
Raphaël Denis
PhD. MSc., Unité “Biologie Fonctionnelle & Adaptative” (BFA) Université Paris Diderot-Paris, Université Paris Diderot-Paris, Paris, France) 

10.00-10.15Selected Oral communication
OP4: Investigation of the glycinergic innervation of TRH neurons in the hypothalamic paraventricular nucleus
Edina Varga
(Institute of Experimental Medicine, Budapest, Hungary, Budapest, Hungary)


Coffee break 


Role of neuroglial interaction in the regulation of neuroendocrine axes 
Vincent Prevot
(Lille France) 

11.15-11.45Molecular biologic tools in the examination of neuroendocrine axes
Balázs Gereben
(Institute of Experimental Medicine, Budapest, Hungary) 
11:45-12.00Selected Oral communication
OP5: Age-dependent responsiveness of the hypothalamo-pituitary-thyroid axis to bacterial lipopolysaccharide induced nonthyroidal illness syndrome
Richárd Sinkó
(Institute of Experimental Medicine, Budapest, Hungary, Budapest, Hungary)
12.00-12.15Selected Oral communication
OP6: Localization of connexin 43 gap junctions and hemichannels on tanycytes of adult mice
Anett Stiftné Szilvásy-Szabó
(Institute of Experimental Medicine, Budapest, Hungary, Budapest, Hungary)




Session 3: Signalling pathways, molecular networks in endocrine tumours as potential therapeutical targets

Chairs: Zoltán Sapi (Budapest, Hungary) and Justo Castaño (Spain)

14.00-14.30Molecular profiling approaches to reach personalized medicine in endocrine malignancies
George Youseff
(Toronto, Canada)

Cell cycle disturbances in pituitary and adrenal tumours
Attila Patocs
(HAS-SE “Lendulet” Hereditary Endocrine Tumours Research Group, Semmelweis University, Department of Laboratory Medicine, Budapest, Hungary) 

15.00-15.15Selected Oral communication 
OP7:  Dehydroandrosterone sulphate (DHEAS) and adrenal tumours in females and males
Milda Sarkinaite
(Institute of Endocrinology, Kaunas, Lithuania) 
15.15-15.30Selected Oral communication 
OP8: Changes of pituitary tumor biology in a patient with GH secreting aggressive pituitary macroadenoma
Dragana Miljic
(Clinic for Endocrinology, Belgrade, Serbia)


Coffee break 


Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer
Clara Alvarez
(University of Santiago de Compostela, Santiago de Compostela Spain) 


Technical aspects of analysis of circulating microRNAs
Henriett Butz (Semmelweis University, Department of Laboratory Medicine, HAS-SE Molecular Medicine Research Group, Budapest, Hungary)

17.00-17.30Novel therapeutical possibilities in adrenocortical cancer
Cristina L. Ronchi
(Division of Endocrinology and Diabetes, University Hospital of Würzburg, Würzburg, Germany) 
17.30-17.45Selected Oral communication
OP9: Differential gene expression profile in classic variant of papillary thyroid carcinoma
Sorina Schipor
(National Institute of Endocrinology “C. I. Parhon”, Bucharest, Romania)


Optional program: Budapest sightseeing by bus (reservation is required)


Meeting Dinner

Friday | February 10th, 2017


Session 4: Methods for evaluation of epigenetic alterations in endocrine tumours

Chairs: Maris Laan (Estonia), Béla Molnár (HAS-SE Molecular Medicine Research Group, Budapest, Hungary)

09.00-09.30Technical aspects of evaluation of DNA methylation
Tamás Arányi (Institute of Enzymology, RCNS, HAS, Budapest, Hungary) 

Targeted molecular therapies in pituitary tumours
Maria Chiara Zatelli (University of Ferrara, Italy) 

10.00-10.15Selected Oral communication
OP10: Dynamic DNA methylation changes due to acute metabolic stress in mice
Borbala Veto
(Institute of Enzymology, RCNS, HAS, Budapest, Hungary)


Coffee break 


MicroRNAs as biomarkers for adrenocortical cancer
Péter Igaz (Semmelweis University, II. Department of Medicine, Budapest, Hungary) 

11.15-11.45Human xenograft models for adrenocortical carcinoma
Constanze Hantel
(Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-University Munich, Germany) 
11.45-12.00Selected Oral communication
OP11: A novel cell population in the human adrenal cortex: carrier of cancer-driving mutations in a physiologically normal organ
Leonardo Guasti
(Queen Mary university of London, London, United Kingdom) 


Closing remarks