Program

Wednesday | February 8th, 2017

14.30 - 15.00

Welcome and opening the course

Prof. Dr. Lászlo Hunyady (Dean Semmelweis University, Faculty of Medicine)



15.00-17.45

Session 1: Genetic and genomic alterations in endocrine tumours, focusing on high throughput methods

Chairs: Márta Korbonits (London, UK) and Péter Igaz (Budapest, Hungary)

15.00-15.30Genetics of adrenocortical tumors focusing on methods and interpretation of results
Guillaume Assie
(Paris, France)
15.30-16.00NGS in genetic diagnosis of Pheo/PGL exome and targeted resequencing, results and pitfalls
Joakim Crona
(Department of Surgical Sciences, Uppsala University, SE-75185, Uppsala Sweden) 
16.00-16.15Selected Oral communication
OP1: Analytical performance of exome sequencing in molecular genetic diagnosis of pheochromocytoma/paraganglioma
Balázs Sarkadi
(HAS-SE “Lendulet” Hereditary Endocrine Tumors Research Group, Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary)


16.15-16.45 

Coffee break 



16.45-17.15

Interpretation of genetic results and their consequences in endocrine tumour syndromes
Francesca Marini
(University of Florence, Florence, Italy)

17.15-17.30Selected Oral communication
OP2: Analysis of MEN1 mutations and potentially MEN1-targeting miRNAs in sporadic and MEN-1 syndrome associated primary hyperparathyroidism
Vince Kornél
Grolmusz Lendület” Hereditary Endocrine Tumours Research Group, Hungarian Academy of Sciences - Semmelweis University, Budapest, Hungary
17.30-17.45Selected Oral communication
OP3: Molecular analysis of the PAX8-PPARγ and RET/PTC rearrangements in follicular cell-derived thyroid tumors in Polish population
Karolina Czarnecka
(Department of Molecular Bases of Medicine, Medical University of Lodz, Lodz, Poland)


19.00 – 

Welcome reception




Thursday | February 9th, 2017

09.00-12.15

Session 2: Neuroendocrinology

Chairs: Krisztina Kovacs (Budapest, Hungary)

09.00-09.30 Central neuronal pathways in the regulation of energy homeostasis
Csaba Fekete
(Institute of Experimental Medicine, Budapest, Hungary)
09.30-10.00 

Examination of the central control of energy homeostasis using metabolic profiling
Raphaël Denis
PhD. MSc., Unité “Biologie Fonctionnelle & Adaptative” (BFA) Université Paris Diderot-Paris, Université Paris Diderot-Paris, Paris, France) 

10.00-10.15Selected Oral communication
OP4: Investigation of the glycinergic innervation of TRH neurons in the hypothalamic paraventricular nucleus
Edina Varga
(Institute of Experimental Medicine, Budapest, Hungary, Budapest, Hungary)


10.15-10.45

Coffee break 



10.45-11.15

Role of neuroglial interaction in the regulation of neuroendocrine axes 
Vincent Prevot
(Lille France) 

11.15-11.45Molecular biologic tools in the examination of neuroendocrine axes
Balázs Gereben
(Institute of Experimental Medicine, Budapest, Hungary) 
11:45-12.00Selected Oral communication
OP5: Age-dependent responsiveness of the hypothalamo-pituitary-thyroid axis to bacterial lipopolysaccharide induced nonthyroidal illness syndrome
Richárd Sinkó
(Institute of Experimental Medicine, Budapest, Hungary, Budapest, Hungary)
12.00-12.15Selected Oral communication
OP6: Localization of connexin 43 gap junctions and hemichannels on tanycytes of adult mice
Anett Stiftné Szilvásy-Szabó
(Institute of Experimental Medicine, Budapest, Hungary, Budapest, Hungary)


12.15-14.00  

Lunch



14.00-17.30

Session 3: Signalling pathways, molecular networks in endocrine tumours as potential therapeutical targets

Chairs: Zoltán Sapi (Budapest, Hungary) and Justo Castaño (Spain)

14.00-14.30Molecular profiling approaches to reach personalized medicine in endocrine malignancies
George Youseff
(Toronto, Canada)
14.30-15.00

Cell cycle disturbances in pituitary and adrenal tumours
Attila Patocs
(HAS-SE “Lendulet” Hereditary Endocrine Tumours Research Group, Semmelweis University, Department of Laboratory Medicine, Budapest, Hungary) 

15.00-15.15Selected Oral communication 
OP7:  Dehydroandrosterone sulphate (DHEAS) and adrenal tumours in females and males
Milda Sarkinaite
(Institute of Endocrinology, Kaunas, Lithuania) 
15.15-15.30Selected Oral communication 
OP8: Changes of pituitary tumor biology in a patient with GH secreting aggressive pituitary macroadenoma
Dragana Miljic
(Clinic for Endocrinology, Belgrade, Serbia)


15.30-16.00

Coffee break 



16.00-16.30

Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer
Clara Alvarez
(University of Santiago de Compostela, Santiago de Compostela Spain) 

16.30-17.00

Technical aspects of analysis of circulating microRNAs
Henriett Butz (Semmelweis University, Department of Laboratory Medicine, HAS-SE Molecular Medicine Research Group, Budapest, Hungary)

17.00-17.30Novel therapeutical possibilities in adrenocortical cancer
Cristina L. Ronchi
(Division of Endocrinology and Diabetes, University Hospital of Würzburg, Würzburg, Germany) 
17.30-17.45Selected Oral communication
OP9: Differential gene expression profile in classic variant of papillary thyroid carcinoma
Sorina Schipor
(National Institute of Endocrinology “C. I. Parhon”, Bucharest, Romania)


17.45

Optional program: Budapest sightseeing by bus (reservation is required)



19.00-

Meeting Dinner




Friday | February 10th, 2017

09.00-12.00

Session 4: Methods for evaluation of epigenetic alterations in endocrine tumours

Chairs: Maris Laan (Estonia), Béla Molnár (HAS-SE Molecular Medicine Research Group, Budapest, Hungary)

09.00-09.30Technical aspects of evaluation of DNA methylation
Tamás Arányi (Institute of Enzymology, RCNS, HAS, Budapest, Hungary) 
09.30-10.00

Targeted molecular therapies in pituitary tumours
Maria Chiara Zatelli (University of Ferrara, Italy) 

10.00-10.15Selected Oral communication
OP10: Dynamic DNA methylation changes due to acute metabolic stress in mice
Borbala Veto
(Institute of Enzymology, RCNS, HAS, Budapest, Hungary)


10.15-10.45

Coffee break 



10.45-11.15

MicroRNAs as biomarkers for adrenocortical cancer
Péter Igaz (Semmelweis University, II. Department of Medicine, Budapest, Hungary) 

11.15-11.45Human xenograft models for adrenocortical carcinoma
Constanze Hantel
(Medizinische Klinik und Poliklinik IV, Ludwig-Maximilians-University Munich, Germany) 
11.45-12.00Selected Oral communication
OP11: A novel cell population in the human adrenal cortex: carrier of cancer-driving mutations in a physiologically normal organ
Leonardo Guasti
(Queen Mary university of London, London, United Kingdom) 


12.00-12.10

Closing remarks



12.10-13.30

Lunch